Dr. Eyler conducts research as part of the Prevention Research Center (PRC) in St. Louis. She is the principal investigator and coordinator of the Physical Activity Policy Research Network (PAPRN), integrating the work of 10 research sites studying the nature and extent of physical activity policy in a variety of settings. She is responsible for evaluation activities for core PRC projects and serves as collaborative investigator on cancer prevention and dissemination grant as she continues to procure external research funding.

Dr. Eyler is a former recipient of the Article of the Year Award for Health Education and Behavior. Her most recent research has been featured in the American Journal of Health Education, Physical Education and Health, and Health Politics Policy Law among others. 

In addition to her other writing and research credits, Eyler has been tapped to edit and update the chapter on exercise and fitness in each new edition of the long-running introductory health text Access to Health.